Stabilizing Role of Platelet P2Y(12) Receptors in Shear-Dependent Thrombus Formation on Ruptured Plaques

BACKGROUND: In most models of experimental thrombosis, healthy blood vessels are damaged. This results in the formation of a platelet thrombus that is stabilized by ADP signaling via P2Y(12) receptors. However, such models do not predict involvement of P2Y(12) in the clinically relevant situation of...

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Autori principali: Nergiz-Unal, Reyhan, Cosemans, Judith M. E. M., Feijge, Marion A. H., van der Meijden, Paola E. J., Storey, Robert F., van Giezen, J. J. J., oude Egbrink, Mirjam G. A., Heemskerk, Johan W. M., Kuijpers, Marijke J. E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2010
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2853564/
https://ncbi.nlm.nih.gov/pubmed/20405028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010130
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