Stabilizing Role of Platelet P2Y(12) Receptors in Shear-Dependent Thrombus Formation on Ruptured Plaques

BACKGROUND: In most models of experimental thrombosis, healthy blood vessels are damaged. This results in the formation of a platelet thrombus that is stabilized by ADP signaling via P2Y(12) receptors. However, such models do not predict involvement of P2Y(12) in the clinically relevant situation of...

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Detalhes bibliográficos
Main Authors: Nergiz-Unal, Reyhan, Cosemans, Judith M. E. M., Feijge, Marion A. H., van der Meijden, Paola E. J., Storey, Robert F., van Giezen, J. J. J., oude Egbrink, Mirjam G. A., Heemskerk, Johan W. M., Kuijpers, Marijke J. E.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2853564/
https://ncbi.nlm.nih.gov/pubmed/20405028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010130
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