Secretory phospholipase A(2) type III enhances α-secretase-dependent amyloid precursor protein processing through alterations in membrane fluidity

In the non-amyloidogenic pathway, amyloid precursor protein (APP) is cleaved by α-secretases to produce α-secretase-cleaved soluble APP (sAPP(α)) with neuroprotective and neurotrophic properties; therefore, enhancing the non-amyloidogenic pathway has been suggested as a potential pharmacological app...

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Detalhes bibliográficos
Main Authors: Yang, Xiaoguang, Sheng, Wenwen, He, Yan, Cui, Jiankun, Haidekker, Mark A., Sun, Grace Y., Lee, James C-M.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2853463/
https://ncbi.nlm.nih.gov/pubmed/19805624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M002287
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