Urinary metabolomics in Fxr-null mice reveals activated adaptive metabolic pathways upon bile acid challenge

Farnesoid X receptor (FXR) is a nuclear receptor that regulates genes involved in synthesis, metabolism, and transport of bile acids and thus plays a major role in maintaining bile acid homeostasis. In this study, metabolomic responses were investigated in urine of wild-type and Fxr-null mice fed ch...

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Autors principals: Cho, Joo-Youn, Matsubara, Tsutomu, Kang, Dong Wook, Ahn, Sung-Hoon, Krausz, Kristopher W., Idle, Jeffrey R., Luecke, Hans, Gonzalez, Frank J.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Biochemistry and Molecular Biology 2010
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2853433/
https://ncbi.nlm.nih.gov/pubmed/19965603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M002923
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