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Cytochrome P450 Regulation by α-Tocopherol in Pxr-Null and PXR-Humanized Mice
The pregnane X receptor (PXR) has been postulated to play a role in the metabolism of α-tocopherol owing to the up-regulation of hepatic cytochrome P450 (P450) 3A in human cell lines and murine models after α-tocopherol treatment. However, in vivo studies confirming the role of PXR in α-tocopherol m...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Pharmacology and Experimental Therapeutics
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3558860/ https://ncbi.nlm.nih.gov/pubmed/23160821 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.112.048009 |
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