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Cytochrome P450 Regulation by α-Tocopherol in Pxr-Null and PXR-Humanized Mice

The pregnane X receptor (PXR) has been postulated to play a role in the metabolism of α-tocopherol owing to the up-regulation of hepatic cytochrome P450 (P450) 3A in human cell lines and murine models after α-tocopherol treatment. However, in vivo studies confirming the role of PXR in α-tocopherol m...

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Bibliografische gegevens
Hoofdauteurs: Johnson, Caroline H., Bonzo, Jessica A., Cheng, Jie, Krausz, Kristopher W., Kang, Dong Wook, Luecke, Hans, Idle, Jeffrey R., Gonzalez, Frank J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The American Society for Pharmacology and Experimental Therapeutics 2013
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3558860/
https://ncbi.nlm.nih.gov/pubmed/23160821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.112.048009
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