Metabolomics reveals a novel vitamin E metabolite and attenuated vitamin E metabolism upon PXR activation

Pregnane X receptor (PXR) is an important nuclear receptor xenosensor that regulates the expression of metabolic enzymes and transporters involved in the metabolism of xenobiotics and endobiotics. In this study, ultra-performance liquid chromatography (UPLC) coupled with electrospray time-of-flight...

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Bibliographic Details
Main Authors: Cho, Joo-Youn, Kang, Dong Wook, Ma, Xiaochao, Ahn, Sung-Hoon, Krausz, Kristopher W., Luecke, Hans, Idle, Jeffrey R., Gonzalez, Frank J.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2666179/
https://ncbi.nlm.nih.gov/pubmed/19141872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M800647-JLR200
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