Transgenic expression of pancreatic secretory trypsin inhibitor-1 rescues SPINK3-deficient mice and restores a normal pancreatic phenotype

Endogenous trypsin inhibitors are synthesized, stored, and secreted by pancreatic acinar cells. It is believed that they play a protective role in the pancreas by inhibiting trypsin within the cell should trypsinogen become prematurely activated. Rodent trypsin inhibitors are highly homologous to hu...

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Bibliographische Detailangaben
Hauptverfasser: Romac, Joelle M.-J., Ohmuraya, Masaki, Bittner, Cathy, Majeed, M. Faraz, Vigna, Steven R., Que, Jianwen, Fee, Brian E., Wartmann, Thomas, Yamamura, Ken-ichi, Liddle, Rodger A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2010
Schlagworte:
Hormones and Signaling
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2853299/
https://ncbi.nlm.nih.gov/pubmed/20110462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00431.2009
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