Pancreatic secretory trypsin inhibitor I reduces the severity of chronic pancreatitis in mice overexpressing interleukin-1β in the pancreas

IL-1β is believed to play a pathogenic role in the development of pancreatitis. Expression of human IL-1β in pancreatic acinar cells produces chronic pancreatitis, characterized by extensive intrapancreatic inflammation, atrophy, and fibrosis. To determine if activation of trypsinogen is important i...

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Autores principales: Romac, Joelle M.-J., Shahid, Rafiq A., Choi, Steve S., Karaca, Gamze F., Westphalen, Christoph B., Wang, Timothy C., Liddle, Rodger A.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Physiological Society 2012
Materias:
Pancreas
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3311433/
https://ncbi.nlm.nih.gov/pubmed/22173919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00287.2011
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