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Role of Intrapancreatic SPINK1/Spink3 Expression in the Development of Pancreatitis
Studies on hereditary pancreatitis have provided evidence in favor of central role for trypsin activity in the disease. Identification of genetic variants of trypsinogen linked the protease to the onset of pancreatitis, and biochemical characterization proposed an enzymatic gain of function as the i...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Frontiers Research Foundation
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3345944/ https://ncbi.nlm.nih.gov/pubmed/22586407 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2012.00126 |
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