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Transport pathways for clearance of human Alzheimer’s amyloid β-peptide and apolipoproteins E and J in the mouse central nervous system

Amyloid β-peptide (Aβ) clearance from the central nervous system (CNS) maintains its low levels in brain. In Alzheimer’s disease, Aβ accumulates in brain possibly due to its faulty CNS clearance and a deficient efflux across the blood-brain barrier (BBB). By using human specific ELISAs, we measured...

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Detalhes bibliográficos
Main Authors: Bell, Robert D., Sagare, Abhay, Friedman, Alan E., Bedi, Gurrinder, Holtzman, David M., Deane, Rashid, Zlokovic, Berislav V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2853021/
https://ncbi.nlm.nih.gov/pubmed/17077814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.jcbfm.9600419
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