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The Acyclic 2,4-Diaminopyrimidine Nucleoside Phosphonate Acts as a Purine Mimetic in HIV-1 Reverse Transcriptase DNA Polymerization

The acyclic pyrimidine nucleoside phosphonate (ANP) phosphonylmethoxyethoxydiaminopyrimidine (PMEO-DAPym) differs from other ANPs in that the aliphatic alkyloxy linker is bound to the C-6 of the 2,4-diaminopyrimidine base through an ether bond, instead of the traditional alkyl linkage to the N-1 or...

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Detalhes bibliográficos
Main Authors: Herman, Brian D., Votruba, Ivan, Holý, Antonin, Sluis-Cremer, Nicolas, Balzarini, Jan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2852949/
https://ncbi.nlm.nih.gov/pubmed/20164190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.096529
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