Humanized SFTPA1 and SFTPA2 Transgenic Mice Reveal Functional Divergence of SP-A1 and SP-A2: FORMATION OF TUBULAR MYELIN IN VIVO REQUIRES BOTH GENE PRODUCTS

Surfactant protein A (SP-A) plays a role in lung innate immunity and surfactant-related functions. Two functional genes, SP-A1 (SFTPA1) and SP-A2 (SFTPA2), are present in humans and primates (rodents have one gene). Single gene SP-A1 or SP-A2 proteins expressed in vitro are functional. To study thei...

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Detalhes bibliográficos
Main Authors: Wang, Guirong, Guo, Xiaoxuan, DiAngelo, Susan, Thomas, Neal J., Floros, Joanna
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2852938/
https://ncbi.nlm.nih.gov/pubmed/20048345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.046243
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