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Human SP-A1 (SFTPA1) variant-specific 3′ UTRs and poly(A) tail differentially affect the in vitro translation of a reporter gene

Human surfactant protein A (SP-A) is encoded by two functional genes (SFTPA1, SFTPA2) with a high degree of sequence identity. Sequence differences among these genes and their genetic variants have been observed at the 5′ and 3′ untranslated regions (UTRs). In this work, we studied the impact on tra...

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Main Authors: Silveyra, Patricia, Wang, Guirong, Floros, Joanna
Formato: Artigo
Idioma:Inglês
Publicado: American Physiological Society 2010
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2957414/
https://ncbi.nlm.nih.gov/pubmed/20693318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00113.2010
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