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Power to detect selective allelic amplification in genome-wide scans of tumor data

Motivation: Somatic amplification of particular genomic regions and selection of cellular lineages with such amplifications drives tumor development. However, pinpointing genes under such selection has been difficult due to the large span of these regions. Our recently-developed method, the amplific...

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Autori principali: Dewal, Ninad, Freedman, Matthew L., LaFramboise, Thomas, Pe'er, Itsik
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2852215/
https://ncbi.nlm.nih.gov/pubmed/20031965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btp694
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