Truncated β-amyloid peptide channels provide an alternative mechanism for Alzheimer’s Disease and Down syndrome

Full-length amyloid beta peptides (Aβ(1–40/42)) form neuritic amyloid plaques in Alzheimer’s disease (AD) patients and are implicated in AD pathology. However, recent transgenic animal models cast doubt on their direct role in AD pathology. Nonamyloidogenic truncated amyloid-beta fragments (Aβ(11–42...

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Detalles Bibliográficos
Main Authors: Jang, Hyunbum, Arce, Fernando Teran, Ramachandran, Srinivasan, Capone, Ricardo, Azimova, Rushana, Kagan, Bruce L., Nussinov, Ruth, Lal, Ratnesh
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2851998/
https://ncbi.nlm.nih.gov/pubmed/20308552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0914251107
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