Truncated β-amyloid peptide channels provide an alternative mechanism for Alzheimer’s Disease and Down syndrome

Full-length amyloid beta peptides (Aβ(1–40/42)) form neuritic amyloid plaques in Alzheimer’s disease (AD) patients and are implicated in AD pathology. However, recent transgenic animal models cast doubt on their direct role in AD pathology. Nonamyloidogenic truncated amyloid-beta fragments (Aβ(11–42...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Jang, Hyunbum, Arce, Fernando Teran, Ramachandran, Srinivasan, Capone, Ricardo, Azimova, Rushana, Kagan, Bruce L., Nussinov, Ruth, Lal, Ratnesh
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2010
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2851998/
https://ncbi.nlm.nih.gov/pubmed/20308552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0914251107
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky