In colorectal cancer mast cells contribute to systemic regulatory T-cell dysfunction

T-regulatory cells (Treg) and mast cells (MC) are abundant in colorectal cancer (CRC) tumors. Interaction between the two is known to promote immune suppression or loss of Treg functions and autoimmunity. Here, we demonstrate that in both human CRC and murine polyposis the outcome of this interactio...

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Main Authors: Blatner, Nichole R., Bonertz, Andreas, Beckhove, Philipp, Cheon, Eric C., Krantz, Seth B., Strouch, Matthew, Weitz, Juergen, Koch, Moritz, Halverson, Amy L., Bentrem, David J., Khazaie, Khashayarsha
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2010
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2851977/
https://ncbi.nlm.nih.gov/pubmed/20308560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0913683107
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