PI3K/AKT signaling is essential for communication between tissue infiltrating mast cells, macrophages, and epithelial cells in colitis-induced cancer

PURPOSE: To understand signaling pathways that shape inflamed tissue and predispose to cancer is critical for effective prevention and therapy of chronic inflammatory diseases. We have explored PI3K activity in human inflammatory bowel diseases (IBD) and mouse colitis models. EXPERIMENTAL DESIGN: We...

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Auteurs principaux: Khan, Mohammad W., Keshavarzian, Ali, Gounaris, Elias, Melson, Joshua E., Cheon, Eric, Blatner, Nichole R., Chen, Zongmin E., Tsai, Fu-Nien, Lee, Goo, Ryu, Hyunji, Barrett, Terrence A., Bentrem, David, Beckhove, Philipp, Khazaie, Khashayarsha
Format: Artigo
Langue:Inglês
Publié: 2013
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3947836/
https://ncbi.nlm.nih.gov/pubmed/23487439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-2623
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