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In colorectal cancer mast cells contribute to systemic regulatory T-cell dysfunction

T-regulatory cells (Treg) and mast cells (MC) are abundant in colorectal cancer (CRC) tumors. Interaction between the two is known to promote immune suppression or loss of Treg functions and autoimmunity. Here, we demonstrate that in both human CRC and murine polyposis the outcome of this interactio...

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Detalhes bibliográficos
Main Authors: Blatner, Nichole R., Bonertz, Andreas, Beckhove, Philipp, Cheon, Eric C., Krantz, Seth B., Strouch, Matthew, Weitz, Juergen, Koch, Moritz, Halverson, Amy L., Bentrem, David J., Khazaie, Khashayarsha
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2851977/
https://ncbi.nlm.nih.gov/pubmed/20308560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0913683107
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