Structure and function of an iterative polyketide synthase thioesterase domain catalyzing Claisen cyclization in aflatoxin biosynthesis

Polyketide natural products possess diverse architectures and biological functions and share a subset of biosynthetic steps with fatty acid synthesis. The final transformation catalyzed by both polyketide synthases (PKSs) and fatty acid synthases is most often carried out by a thioesterase (TE). The...

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Библиографические подробности
Главные авторы: Korman, Tyler Paz, Crawford, Jason M., Labonte, Jason W., Newman, Adam G., Wong, Justin, Townsend, Craig A., Tsai, Shiou-Chuan
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2010
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2851968/
https://ncbi.nlm.nih.gov/pubmed/20332208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0913531107
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