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Deconstruction of Iterative Multidomain Polyketide Synthase Function

PksA, which initiates biosynthesis of the environmental carcinogen aflatoxin B1, is one of the multidomain iterative polyketide synthases (IPKSs), a large, poorly understood family of biosynthetic enzymes. We found that dissection of PksA and its reconstitution from selected sets of domains allows t...

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Bibliografische gegevens
Hoofdauteurs: Crawford, Jason M., Thomas, Paul M., Scheerer, Jonathan R., Vagstad, Anna L., Kelleher, Neil L., Townsend, Craig A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2008
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2480491/
https://ncbi.nlm.nih.gov/pubmed/18403714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1154711
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