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Huwe1 ubiquitin ligase is essential to synchronize neuronal and glial differentiation in the developing cerebellum
We have generated a knockout mouse strain in which the gene coding for the ubiquitin ligase Huwe1 has been inactivated in cerebellar granule neuron precursors (CGNPs) and radial glia. These mice have a high rate of postnatal lethality and profound cerebellar abnormalities. The external granule layer...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2010
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2851916/ https://ncbi.nlm.nih.gov/pubmed/20231446 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0912874107 |
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