The N-Myc-DLL3 cascade is suppressed by the ubiquitin ligase Huwe1 to inhibit proliferation and promote neurogenesis in the developing brain

Self-renewal and proliferation of neural stem cells and the decision to initiate neurogenesis are the crucial events directing brain development. Here we show that the ubiquitin ligase Huwe1 operates upstream of the N-Myc-DLL3-Notch pathway to control neural stem cell activity and promote neurogenes...

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Hauptverfasser: Zhao, Xudong, Arca, Domenico D', Lim, Wei Keat, Brahmachary, Manisha, Carro, Maria Stella, Ludwig, Thomas, Cardo, Carlos Cordon, Guillemot, Francois, Aldape, Ken, Califano, Andrea, Iavarone, Antonio, Lasorella, Anna
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2769073/
https://ncbi.nlm.nih.gov/pubmed/19686682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2009.07.009
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