The N-Myc-DLL3 cascade is suppressed by the ubiquitin ligase Huwe1 to inhibit proliferation and promote neurogenesis in the developing brain

Self-renewal and proliferation of neural stem cells and the decision to initiate neurogenesis are the crucial events directing brain development. Here we show that the ubiquitin ligase Huwe1 operates upstream of the N-Myc-DLL3-Notch pathway to control neural stem cell activity and promote neurogenes...

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Detalhes bibliográficos
Main Authors: Zhao, Xudong, Arca, Domenico D', Lim, Wei Keat, Brahmachary, Manisha, Carro, Maria Stella, Ludwig, Thomas, Cardo, Carlos Cordon, Guillemot, Francois, Aldape, Ken, Califano, Andrea, Iavarone, Antonio, Lasorella, Anna
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2769073/
https://ncbi.nlm.nih.gov/pubmed/19686682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2009.07.009
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