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Induction of TGF-β1 and TGF-β1–dependent predominant Th17 differentiation by group A streptococcal infection

Recurrent group A Streptococcus (GAS) tonsillitis and associated autoimmune diseases indicate that the immune response to this organism can be ineffective and pathological. TGF-β1 is recognized as an essential signal for generation of regulatory T cells (Tregs) and T helper (Th) 17 cells. Here, the...

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Hlavní autoři: Wang, Beinan, Dileepan, Thamotharampillai, Briscoe, Sarah, Hyland, Kendra A., Kang, Johnthomas, Khoruts, Alexander, Cleary, P. Patrick
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2851870/
https://ncbi.nlm.nih.gov/pubmed/20231435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0904831107
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