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Maximum entropy models for antibody diversity

Recognition of pathogens relies on families of proteins showing great diversity. Here we construct maximum entropy models of the sequence repertoire, building on recent experiments that provide a nearly exhaustive sampling of the IgM sequences in zebrafish. These models are based solely on pairwise...

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Detalhes bibliográficos
Main Authors: Mora, Thierry, Walczak, Aleksandra M., Bialek, William, Callan, Curtis G.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2851784/
https://ncbi.nlm.nih.gov/pubmed/20212159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1001705107
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