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Inferring processes underlying B-cell repertoire diversity
We quantify the VDJ recombination and somatic hypermutation processes in human B cells using probabilistic inference methods on high-throughput DNA sequence repertoires of human B-cell receptor heavy chains. Our analysis captures the statistical properties of the naive repertoire, first after its in...
Shranjeno v:
| izdano v: | Philos Trans R Soc Lond B Biol Sci |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
The Royal Society
2015
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4528420/ https://ncbi.nlm.nih.gov/pubmed/26194757 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rstb.2014.0243 |
| Oznake: |
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