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Force-Induced Bidirectional Stepping of Cytoplasmic Dynein

Cytoplasmic dynein is a minus-end-directed microtubule motor whose mechanism of movement remains poorly understood. Here, we use optical tweezers to examine the force-dependent stepping behavior of yeast cytoplasmic dynein. We find that dynein primarily advances in 8 nm increments but takes other si...

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Main Authors: Gennerich, Arne, Carter, Andrew P., Reck-Peterson, Samara L., Vale, Ronald D.
格式: Artigo
語言:Inglês
出版: 2007
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2851641/
https://ncbi.nlm.nih.gov/pubmed/18045537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2007.10.016
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