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Force production of human cytoplasmic dynein is limited by its processivity

Cytoplasmic dynein is a highly complex motor protein that generates forces toward the minus end of microtubules. Using optical tweezers, we demonstrate that the low processivity (ability to take multiple steps before dissociating) of human dynein limits its force generation due to premature microtub...

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Publicat a:Sci Adv
Autors principals: Brenner, Sibylle, Berger, Florian, Rao, Lu, Nicholas, Matthew P., Gennerich, Arne
Format: Artigo
Idioma:Inglês
Publicat: American Association for the Advancement of Science 2020
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7141836/
https://ncbi.nlm.nih.gov/pubmed/32285003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaz4295
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