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Force production of human cytoplasmic dynein is limited by its processivity
Cytoplasmic dynein is a highly complex motor protein that generates forces toward the minus end of microtubules. Using optical tweezers, we demonstrate that the low processivity (ability to take multiple steps before dissociating) of human dynein limits its force generation due to premature microtub...
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| Published in: | Sci Adv |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Association for the Advancement of Science
2020
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7141836/ https://ncbi.nlm.nih.gov/pubmed/32285003 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaz4295 |
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