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Molecular mechanism of cytoplasmic dynein tension sensing

Cytoplasmic dynein is the most complex cytoskeletal motor protein and is responsible for numerous biological functions. Essential to dynein’s function is its capacity to respond anisotropically to tension, so that its microtubule-binding domains bind microtubules more strongly when under backward lo...

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Pubblicato in:Nat Commun
Autori principali: Rao, Lu, Berger, Florian, Nicholas, Matthew P., Gennerich, Arne
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6659695/
https://ncbi.nlm.nih.gov/pubmed/31350388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11231-8
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