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Regulatory ATPase Sites of Cytoplasmic Dynein Affect Processivity and Force Generation
The heavy chain of cytoplasmic dynein contains four nucleotide-binding domains referred to as AAA1–AAA4, with the first domain (AAA1) being the main ATP hydrolytic site. Although previous studies have proposed regulatory roles for AAA3 and AAA4, the role of ATP hydrolysis at these sites remains elus...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2533788/ https://ncbi.nlm.nih.gov/pubmed/18650442 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M802951200 |
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