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STIM1 Mutation Associated with a Syndrome of Immunodeficiency and Autoimmunity
A mutation in ORAI1, the gene encoding the pore-forming subunit of the Ca(2+)-release–activated Ca(2+) (CRAC) channel, abrogates the store-operated entry of Ca(2+) into cells and impairs lymphocyte activation. Stromal interaction molecule 1 (STIM1) in the endoplasmic reticulum activates ORAI1–CRAC c...
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| Autori principali: | , , , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2851618/ https://ncbi.nlm.nih.gov/pubmed/19420366 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa0900082 |
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