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Immunodeficiency due to mutations in ORAI1 and STIM1

Lymphocyte activation requires Ca(2+) influx through specialized Ca(2+) channels in the plasma membrane. In T cells the predominant Ca(2+) channel is the Ca(2+) release activated Ca(2+) (CRAC) channel encoded by the gene ORAI1. ORAI1 is activated by stromal interaction molecule (STIM) 1 that is loca...

詳細記述

保存先:
書誌詳細
主要な著者: Feske, Stefan, Picard, Capucine, Fischer, Alain
フォーマット: Artigo
言語:Inglês
出版事項: 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2856745/
https://ncbi.nlm.nih.gov/pubmed/20189884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clim.2010.01.011
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