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Immunodeficiency due to mutations in ORAI1 and STIM1
Lymphocyte activation requires Ca(2+) influx through specialized Ca(2+) channels in the plasma membrane. In T cells the predominant Ca(2+) channel is the Ca(2+) release activated Ca(2+) (CRAC) channel encoded by the gene ORAI1. ORAI1 is activated by stromal interaction molecule (STIM) 1 that is loca...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2856745/ https://ncbi.nlm.nih.gov/pubmed/20189884 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clim.2010.01.011 |
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