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T-cell specific deletion of STIM1 and STIM2 protects mice from EAE by impairing the effector functions of Th1 and Th17 cells
T cell function is dependent on store-operated Ca(2+) influx that is activated by the stromal interaction molecules (STIM) 1 and 2. We show that mice with T-cell specific deletion of STIM1 or STIM2 are protected from experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosi...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2010
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3517124/ https://ncbi.nlm.nih.gov/pubmed/21061435 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201040614 |
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