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T-cell specific deletion of STIM1 and STIM2 protects mice from EAE by impairing the effector functions of Th1 and Th17 cells

T cell function is dependent on store-operated Ca(2+) influx that is activated by the stromal interaction molecules (STIM) 1 and 2. We show that mice with T-cell specific deletion of STIM1 or STIM2 are protected from experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosi...

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Detalhes bibliográficos
Main Authors: Ma, Jian, McCarl, Christie-Ann, Khalil, Sara, Lüthy, Kevin, Feske, Stefan
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3517124/
https://ncbi.nlm.nih.gov/pubmed/21061435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201040614
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