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TGF-β promotes Th17 cell development through inhibition of SOCS3
TGF-β, together with IL-6 and IL-21, promotes Th17 cell development. IL-6 and IL-21 induce activation of STAT3, which is crucial for Th17 cell differentiation, as well as the expression of SOCS3, a major negative feedback regulator of STAT3-activating cytokines that negatively regulates Th17 cells....
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| Autori principali: | , , , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2851540/ https://ncbi.nlm.nih.gov/pubmed/19535626 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0801986 |
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