TGF-β promotes Th17 cell development through inhibition of SOCS3

TGF-β, together with IL-6 and IL-21, promotes Th17 cell development. IL-6 and IL-21 induce activation of STAT3, which is crucial for Th17 cell differentiation, as well as the expression of SOCS3, a major negative feedback regulator of STAT3-activating cytokines that negatively regulates Th17 cells....

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Bibliografiske detaljer
Main Authors: Qin, Hongwei, Wang, Lanfang, Feng, Ting, Elson, Charles O., Niyongere, Sandrine A., Lee, Sun Jung, Reynolds, Stephanie L., Weaver, Casey T., Roarty, Kevin, Serra, Rosa, Benveniste, Etty N., Cong, Yingzi
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2851540/
https://ncbi.nlm.nih.gov/pubmed/19535626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0801986
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