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Paclitaxel promotes a caspase 8-mediated apoptosis via death effector domain association with microtubules

Microtubule-perturbing drugs have become front line chemotherapeutics, inducing cell cycle crisis as a major mechanism of action. However, these agents exhibit pleiotropic effects on cells, and can induce apoptosis via other means. Paclitaxel, a microtubule-stabilizing agent, induces a caspase-depen...

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Detaylı Bibliyografya
Asıl Yazarlar: Mielgo, Ainhoa, Torres, Vicente A., Clair, Kiran, Barbero, Simone, Stupack, Dwayne G.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2009
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2851247/
https://ncbi.nlm.nih.gov/pubmed/19668227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2009.210
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