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Oxyferryl Heme and Not Tyrosyl Radical Is the Likely Culprit in Prostaglandin H Synthase-1 Peroxidase Inactivation
Prostaglandin H synthase-1 (PGHS-1) is a bifunctional heme protein catalyzing both a peroxidase reaction, in which peroxides are converted to alcohols, and a cyclooxygenase reaction, in which arachidonic acid is converted into prostaglandin G(2). Reaction of PGHS-1 with peroxide forms Intermediate I...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2851183/ https://ncbi.nlm.nih.gov/pubmed/17209563 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi061859h |
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