Automated Detection of Inaccurate and Imprecise Transitions in Peptide Quantification by Multiple Reaction Monitoring Mass Spectrometry

BACKGROUND: Multiple reaction monitoring mass spectrometry (MRM-MS) of peptides with stable isotope–labeled internal standards (SISs) is increasingly being used to develop quantitative assays for proteins in complex biological matrices. These assays can be highly precise and quantitative, but the fr...

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Hauptverfasser: Abbatiello, Susan E., Mani, D. R., Keshishian, Hasmik, Carr, Steven A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2851178/
https://ncbi.nlm.nih.gov/pubmed/20022980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1373/clinchem.2009.138420
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