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Substrate and cofactor requirements of indoleamine 2,3-dioxygenase in interferon-gamma treated cells: Utilization of oxygen rather than superoxide

Much attention has been paid in initial biochemical studies on the ability of indoleamine 2,3-dioxygenase to use superoxide as substrate to cleave tryptophan to N-formyl kynurenine. This ability, however, is limited to the ferric form of the enzyme only, whereas the ferrous form requires oxygen rath...

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Dettagli Bibliografici
Autori principali: Werner, E.R., Werner-Felmayer, Gabriele
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2007
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2851152/
https://ncbi.nlm.nih.gov/pubmed/17430107
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