Interferon gamma-resistant mutants are defective in the induction of indoleamine 2,3-dioxygenase.
Several mutants of the human cell line ME-180 resistant to the cytotoxic effect of interferon gamma (IFN-gamma) were isolated after mutagenesis with nitrosoguanidine. Two of the mutant lines (ME-IR3b and ME-IR6g) examined had significantly lower induction levels of the L-tryptophan (L-Trp) degradati...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1989
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC298012/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2506547/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.18.7144 |
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