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Cysteine 95 and other residues influence the regulatory effects of Histidine 69 mutations on Human Immunodeficiency Virus Type 1 protease autoprocessing

BACKGROUND: Regulated autoprocessing of HIV Gag-Pol precursor is required for the production of mature and fully active protease. We previously reported that H69E mutation in a pseudo wild type protease sequence significantly (>20-fold) impedes protease maturation in an in vitro autoprocessing as...

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Detalhes bibliográficos
Main Authors: Huang, Liangqun, Hall, Alyssa, Chen, Chaoping
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2850873/
https://ncbi.nlm.nih.gov/pubmed/20331855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-7-24
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