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Understanding HIV-1 protease autoprocessing for novel therapeutic development

In the infected cell, HIV-1 protease (PR) is initially synthesized as part of the GagPol polyprotein. PR autoprocessing is a virus-specific process by which the PR domain embedded in the precursor catalyzes proteolytic reactions responsible for liberation of free mature PRs, which then recognize and...

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Detalles Bibliográficos
Autores principales: Huang, Liangqun, Chen, Chaoping
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3826259/
https://ncbi.nlm.nih.gov/pubmed/23859204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4155/fmc.13.89
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