Extensive enteric nervous system abnormalities in mice transgenic for artificial chromosomes containing Parkinson disease-associated α-synuclein gene mutations precede central nervous system changes

Parkinson disease (PD) is a neurodegenerative disease with motor as well as non-motor signs in the gastrointestinal tract that include dysphagia, gastroparesis, prolonged gastrointestinal transit time, constipation and difficulty with defecation. The gastrointestinal dysfunction commonly precedes th...

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Autors principals: Kuo, Yien-Ming, Li, Zhishan, Jiao, Yun, Gaborit, Nathalie, Pani, Amar K., Orrison, Bonnie M., Bruneau, Benoit G., Giasson, Benoit I., Smeyne, Richard J., Gershon, Michael D., Nussbaum, Robert L.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2010
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2850613/
https://ncbi.nlm.nih.gov/pubmed/20106867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddq038
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