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Naked Plasmid DNA Formulation: Effect of Different Disaccharides on Stability after Lyophilisation
Since plasmid DNA (pDNA) is unstable in solution, lyophilisation can be used to increase product shelf life. To prevent stress on pDNA molecules during lyophilisation, cryo- and lyoprotectants have to be added to the formulation. This study assessed the effect of disaccharides on naked pDNA stabilit...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Springer US
2010
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2850488/ https://ncbi.nlm.nih.gov/pubmed/20204715 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12249-010-9391-2 |
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