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Naked Plasmid DNA Formulation: Effect of Different Disaccharides on Stability after Lyophilisation

Since plasmid DNA (pDNA) is unstable in solution, lyophilisation can be used to increase product shelf life. To prevent stress on pDNA molecules during lyophilisation, cryo- and lyoprotectants have to be added to the formulation. This study assessed the effect of disaccharides on naked pDNA stabilit...

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Sonraí Bibleagrafaíochta
Main Authors: Quaak, Susanne G. L., Haanen, John B. A. G., Beijnen, Jos H., Nuijen, Bastiaan
Formáid: Artigo
Teanga:Inglês
Foilsithe: Springer US 2010
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2850488/
https://ncbi.nlm.nih.gov/pubmed/20204715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12249-010-9391-2
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