Dose Response in Rodents and Nonhuman Primates After Hydrodynamic Limb Vein Delivery of Naked Plasmid DNA

The efficacy of gene therapy mediated by plasmid DNA (pDNA) depends on the selection of suitable vectors and doses. Using hydrodynamic limb vein (HLV) injection to deliver naked pDNA to skeletal muscles of the limbs, we evaluated key parameters that affect expression in muscle from genes encoded in...

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Detalhes bibliográficos
Main Authors: Wooddell, Christine I., Hegge, Julia O., Zhang, Guofeng, Sebestyén, Magdolna G., Noble, Mark, Griffin, Jacob B., Pfannes, Loretta V., Herweijer, Hans, Hagstrom, James E., Braun, Serge, Huss, Thierry, Wolff, Jon A.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2011
Assuntos:
Methods
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3135275/
https://ncbi.nlm.nih.gov/pubmed/21338336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2010.160
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