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Novel p47(phox)-related organizers regulate NADPH oxidase 1 (Nox1) activity and localization

The mechanisms that determine localized formation of reactive oxygen species (ROS) via NADPH oxidases (Nox) in nonphagocytic cells are unknown. We show that the c-Src substrate proteins Tks4 and Tks5 are functional members of a p47(phox)-related organizer superfamily. Tks proteins selectively suppor...

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Detalhes bibliográficos
Main Authors: Gianni, Davide, Diaz, Begoña, Taulet, Nicolas, Fowler, Bruce, Courtneidge, Sara A., Bokoch, Gary M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2850287/
https://ncbi.nlm.nih.gov/pubmed/19755710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2000370
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