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Intracellular Delivery of a Proapoptotic Peptide via Conjugation to a RAFT Synthesized Endosomolytic Polymer
Peptides derived from the third B-cell lymphoma 2 (Bcl-2) homology domain (BH3) can heterodimerize with anti-apoptotic Bcl-2 family members to block their activity and trigger apoptosis. Use of these peptides presents a viable anti-cancer approach, but delivery barriers limit the broad application o...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2849913/ https://ncbi.nlm.nih.gov/pubmed/19968323 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp9002267 |
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