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The Structure of p85ni in Class IA Phosphoinositide 3-Kinase Exhibits Interdomain Disorder

Regulation of the Class IA PI 3-kinase involves inhibition and stabilization of the catalytic subunit (p110) by the regulatory subunit (p85). Regulation is achieved by 2 major contacts: a stable interface involving the Adapter-Binding Domain (ABD) of p110 and the inter-SH2 (iSH2) domain of p85, and...

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書誌詳細
主要な著者: Sen, K. Ilker, Wu, Haiyan, Backer, Jonathan M., Gerfen, Gary J.
フォーマット: Artigo
言語:Inglês
出版事項: 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2849757/
https://ncbi.nlm.nih.gov/pubmed/20131869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi902171d
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